The “gray area” for hemp-derived cannabinoids is closing rapidly.
As of early 2026, several states have moved to strictly regulate or outright ban semi-synthetic cannabinoids (SSCs) like Δ8, HHC, and THCP. These changes aren’t just about potency, they are about Total THC compliance and the safety of the chemical conversion process.
If your current COAs don’t accurately distinguish between these isomers, your products could be at risk of:
- State-level seizures for exceeding “Total THC” thresholds.
- Product liability due to undisclosed semi-synthetic content.
- Retailer rejection as vendors demand “Defensible Data” for their shelves.
Expanded Cannabinoids Panel
View the panel specifications, including analytes, matrix types, and method accreditations.
That’s why we’ve updated our Expanded Cannabinoid panel to cover an additional 9 compounds (growing the total from 22 to 31 compounds). It’s specifically designed to help you navigate these new legislative hurdles.
If you’re an existing client, your ordering process and pricing stay exactly the same. You’ll simply see additional analytes reflected on your report.
SC Labs clients are already using our expanded panel to stay on shelves.
Introduction & Summary
The Semi-Synthetic Cannabinoids Analysis is an expanded potency testing method designed to identify and quantify a broad spectrum of both naturally occurring and semi-synthetic cannabinoids. This method utilizes two separate analyses — standard potency and semi-synthetic compounds — combined into a single report to meet regulatory requirements and provide a comprehensive chemical profile for hemp-derived and manufactured cannabis products.
It is specifically engineered to resolve common interferences and accurately identify compounds like HHC and Δ10 isomers. Analysis is performed using High-Performance Liquid Chromatography with Diode Array Detection (HPLC-DAD).
Reported Analytes
The method targets a wide range of compounds, including standard cannabinoids and emerging semi-synthetic analogs. There are 32 cannabinoids analyzed by the method, with 17 of those compounds being novel. This results in 31 reported cannabinoids on the Certificate of Analysis (COA).
Standard & Minor Cannabinoids
- CBD
- CBG
- CBN
- CBC
- CBDV
- CBL
THC Isomers & Analogs
- Δ9THC
- Δ8THC
- Δ9THCV
- Δ8THCV
- EXO-THC
- Δ8-iso-THC
- Δ10-THC
Acetates & Other Analogs
- Δ9THC-Acetate
Acidics
- THCa
- THCVa
- CBDa
- CBDVa
- CBCa
- CBGa
HHC Isomers
- 9S-HHC
- 9R-HHC
Accreditations & Certifications
ISO/IEC 17025
Developed for inclusion in updated method validation reports for ISO and state agency submission.
Matrix Types & Minimum Sample Mass
The method is validated for a variety of cannabis and hemp matrices.
| Matrix Category | Min Sample Size (g) |
|---|---|
| Flower | 1 g |
| Concentrate | 1 g |
| Infused | 3 g |
Let’s talk about your testing needs
Our experts are always ready to answer your questions.